Enabling functionality and translation fidelity characterization of mRNA-based vaccines with a platform-based, antibody-free mass spectrometry detection approach

Abstract excerpt

The success of mRNA-based therapeutics and vaccines can be attributed to their rapid development, adaptability to new disease variants, and scalable production. Modified ribonucleotides are often used in mRNA-based vaccines or therapeutics to enhance stability and reduce immunogenicity. However, substituting uridine with N 1 -methylpseudouridine has recently been shown to result in +1 ribosomal frameshifting that...

Topics

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• Immunotherapy and Immune Responses
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Viral Infections and Immunology Research
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

29718e85-9fc7-5669-b03d-471d23382a67

DOI

10.1101/2024.05.14.594137