Article

CHAF1A promotes the translesion DNA synthesis pathway in response to DNA replication stress

2023-04-22

Abstract excerpt

The translesion DNA synthesis (TLS) pathway mediated by proliferating cell nuclear antigen (PCNA) monoubiquitination is an essential mechanism by which cancer cells bypass DNA damage caused by DNA replication stress to maintain genomic stability and cell survival. Chromatin assembly factor 1 subunit A (CHAF1A) traditionally promotes histone assembly during DNA replication. Here, we revealed that CHAF1A is a novel...

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Literature Corpus work: 6824963f-69bc-5634-b387-27f09b489c81
DOI: 10.1101/2023.04.21.537900

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