Article

Mutation signatures reveal biological processes in human cancer

2016-01-13

Abstract excerpt

Replication errors in the genome accumulate from a variety of mutational processes, which leave a history of mutations on the affected genome. The relative contribution of each mutational process has been characterized by non-negative matrix factorization and has lead to deeper insight into both mutational and repair processes contributing to cancer. However current implementations of NMF have left unresolved some...

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Identifiers and source

Literature Corpus work: 6ea18847-bc03-554d-9a23-21ffc5114c66
DOI: 10.1101/036541

Open publication

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