Article

SNMF: Integrated Learning of Mutational Signatures and Prediction of DNA Repair Deficiencies

2024-11-28

Abstract excerpt

<h4>Motivation</h4> Many tumours show deficiencies in DNA damage response (DDR), which influence tumorigenesis and progression, but also expose vulnerabilities with therapeutic potential. Assessing which patients might benefit from DDR-targeting therapy requires knowledge of tumour DDR deficiency status, with mutational signatures reportedly better predictors than loss of function mutations in select genes. Howev...

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Literature Corpus work: 5349f940-c779-5551-bcfe-838aa8a0f4cb
DOI: 10.1101/2024.11.27.624656

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