Article
Prominent features of the amino acid mutation landscape in cancer.
PloS one - 1 Jan 2017
Szpiech Zachary A, Strauli Nicolas B, White Katharine A, Ruiz Diego Garrido, Jacobson Matthew P, Barber Diane L, Hernandez Ryan D
Abstract excerpt
Cancer can be viewed as a set of different diseases with distinctions based on tissue origin, driver mutations, and genetic signatures. Accordingly, each of these distinctions have been used to classify cancer subtypes and to reveal common features. Here, we present a different analysis of cancer based on amino acid mutation signatures. Non-negative Matrix Factorization and principal component analysis of 29...
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