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Article

Mutational signature learning with supervised negative binomial non-negative matrix factorization.

Bioinformatics (Oxford, England) - 1 Jul 2020

Lyu Xinrui, Garret Jean, Rätsch Gunnar, Lehmann Kjong-Van

Abstract excerpt

MOTIVATION: Understanding the underlying mutational processes of cancer patients has been a long-standing goal in the community and promises to provide new insights that could improve cancer diagnoses and treatments. Mutational signatures are summaries of the mutational processes, and improving the derivation of mutational signatures can yield new discoveries previously obscured by technical and biological...

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PMID: 32657388
DOI: 10.1093/bioinformatics/btaa473
PMCID: PMC7355241

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