Article

An essential checkpoint for TLR9 signaling is release from Unc93b1 in endosomes

2018-09-05

Abstract excerpt

<h4>Abstract:</h4> Nucleic acid-sensing Toll-like receptors (TLRs) are subject to complex regulation to facilitate recognition of microbial DNA and RNA while limiting recognition of self-nucleic acids 1 . Failure to properly regulate nucleic acid-sensing TLRs can lead to autoimmune and autoinflammatory disease 2-6 . Intracellular localization of these receptors is thought to be critical for self vs. non-self di...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ea0a73c-1767-5139-9687-dde33362dcc5
DOI: 10.1101/410092

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An essential checkpoint for TLR9 signaling is release from Unc93b1 in endosomesDOI 10.1101/410092Read

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.Semantic proximity Read

Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.Semantic proximity Read

UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.Semantic proximity Read

Endosome dysfunction leads to gain-of-function TLR7 and human lupusSemantic proximity Read

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.Semantic proximity Read

Disrupted degradative sorting of TLR7 is associated with human lupus.Semantic proximity Read

UNC93B1 mediates differential trafficking of endosomal TLRs.Semantic proximity Read

Transmembrane mutations in Toll-like receptor 9 bypass the requirement for ectodomain proteolysis and induce fatal inflammation.Semantic proximity Read

A novel <i>UNC93B1</i> gain-of-function mutation leads to TLR7 and TLR8 hyperactivation and systemic lupus erythematosusSemantic proximity Read

Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization.Semantic proximity Read

Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.Semantic proximity Read

Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.Semantic proximity Read