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Article

UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.

PloS one - 1 Jan 2011

Itoh Hiroki, Tatematsu Megumi, Watanabe Ayako, Iwano Katsunori, Funami Kenji, Seya Tsukasa, Matsumoto Misako

Abstract excerpt

Toll-like receptors (TLRs) 3, 7, 8, and 9 are localized to intracellular compartments where they encounter foreign or self nucleic acids and activate innate and adaptive immune responses. The endoplasmic reticulum (ER)-resident membrane protein, UNC93B1, is essential for intracellular trafficking and endolysosomal targeting of TLR7 and TLR9. TLR8 is phylogenetically and structurally related to TLR7 and TLR9, but...

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Share to Endoplasmic Reticulum
Share to Endosomes
Share to Immunity, Innate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Transport Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 22164301
DOI: 10.1371/journal.pone.0028500
PMCID: PMC3229609

Genes

TLR8
TLR7
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.PMID 22164301Read ↗

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.Semantic proximity Read ↗

UNC93B1 mediates differential trafficking of endosomal TLRs.Semantic proximity Read ↗

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.Semantic proximity Read ↗

An essential checkpoint for TLR9 signaling is release from Unc93b1 in endosomesSemantic proximity Read ↗

Secretion of the human Toll-like receptor 3 ectodomain is affected by single nucleotide polymorphisms and regulated by Unc93b1.Semantic proximity Read ↗

A novel <i>UNC93B1</i> gain-of-function mutation leads to TLR7 and TLR8 hyperactivation and systemic lupus erythematosusSemantic proximity Read ↗

Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.Semantic proximity Read ↗

Disrupted degradative sorting of TLR7 is associated with human lupus.Semantic proximity Read ↗

Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases.Semantic proximity Read ↗

Endosome dysfunction leads to gain-of-function TLR7 and human lupusSemantic proximity Read ↗

Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization.Semantic proximity Read ↗

Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.Semantic proximity Read ↗

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