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Article

Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2013

Kim Jihee, Huh Jiwon, Hwang Misun, Kwon Eun-Hye, Jung Da-Jung, Brinkmann Melanie M, Jang Myoung Ho, Ploegh Hidde L, Kim You-Me

Abstract excerpt

TLRs are divided into two groups based on their subcellular localization patterns. TLR1, 2, 4, 5, and 6 are expressed on the cell surface, whereas the nucleotide-sensing TLRs, such as TLR3, 7, 8, and 9 stay mainly inside cells. The polytopic membrane protein UNC93B1 physically interacts with the nucleotide-sensing TLRs and delivers them from the endoplasmic reticulum to endolysosomes, where the TLRs recognize...

Read the complete abstract on PubMed

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Share to Dendritic Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Toll-Like Receptor 3

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Source

Identifiers

PMID: 23585677
DOI: 10.4049/jimmunol.1202767

Genes

TLR3
TLR9
TLR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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