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Article

Tyrosine 870 of TLR9 is critical for receptor maturation rather than phosphorylation-dependent ligand-induced signaling.

PloS one - 1 Jan 2018

Biswas Chhanda, Rao Sheila, Slade Katharine, Hyman David, Dersh Devin, Mantegazza Adriana R, Zoltick Philip W, Marks Michael S, Argon Yair, Behrens Edward M

Abstract excerpt

Toll like receptors (TLRs) share a conserved structure comprising the N-terminal ectodomain, a transmembrane segment and a C-terminal cytoplasmic Toll/IL-1 receptor (TIR) domain. Proper assembly of the TIR domain is crucial for signal transduction; however, the contribution of individual motifs within the TIR domain to TLR trafficking and signaling remains unclear. We targeted a highly conserved tyrosine (Y870)...

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Source

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Identifiers

PMID: 30024926
DOI: 10.1371/journal.pone.0200913
PMCID: PMC6053202

Genes

TLR9
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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