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Article

Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.

Immunity - 22 Jul 2011

Fukui Ryutaro, Saitoh Shin-Ichiroh, Kanno Atsuo, Onji Masahiro, Shibata Takuma, Ito Akihiko, Onji Morikazu, Matsumoto Mitsuru, Akira Shizuo, Yoshida Nobuaki, Miyake Kensuke

Abstract excerpt

Toll-like receptor-7 (TLR7) and 9, innate immune sensors for microbial RNA or DNA, have been implicated in autoimmunity. Upon activation, TLR7 and 9 are transported from the endoplasmic reticulum (ER) to endolysosomes for nucleic acid sensing by an ER-resident protein, Unc93B1. Little is known, however, about a role for sensor transportation in controlling autoimmunity. TLR9 competes with TLR7 for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21683627
DOI: 10.1016/j.immuni.2011.05.010

Genes

TLR7
TLR9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.PMID 21683627Read ↗

A novel <i>UNC93B1</i> gain-of-function mutation leads to TLR7 and TLR8 hyperactivation and systemic lupus erythematosusSemantic proximity Read ↗

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes.Semantic proximity Read ↗

Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans.Semantic proximity Read ↗

An essential checkpoint for TLR9 signaling is release from Unc93b1 in endosomesSemantic proximity Read ↗

Disrupted degradative sorting of TLR7 is associated with human lupus.Semantic proximity Read ↗

Endosome dysfunction leads to gain-of-function TLR7 and human lupusSemantic proximity Read ↗

UNC93B1 physically associates with human TLR8 and regulates TLR8-mediated signaling.Semantic proximity Read ↗

UNC93B1 mediates differential trafficking of endosomal TLRs.Semantic proximity Read ↗

Immune dysregulation caused by novel gain-of-function <i>UNC93B1</i> variant with enhanced antigen presentationSemantic proximity Read ↗

An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection.Semantic proximity Read ↗

Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosusSemantic proximity Read ↗

Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus.Semantic proximity Read ↗

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