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Article

UNC93B1 mediates differential trafficking of endosomal TLRs.

eLife - 19 Feb 2013

Lee Bettina L, Moon Joanne E, Shu Jeffrey H, Yuan Lin, Newman Zachary R, Schekman Randy, Barton Gregory M

Abstract excerpt

UNC93B1, a multipass transmembrane protein required for TLR3, TLR7, TLR9, TLR11, TLR12, and TLR13 function, controls trafficking of TLRs from the endoplasmic reticulum (ER) to endolysosomes. The mechanisms by which UNC93B1 mediates these regulatory effects remain unclear. Here, we demonstrate that UNC93B1 enters the secretory pathway and directly controls the packaging of TLRs into COPII vesicles that bud from...

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Share to Adaptor Protein Complex 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23426999
DOI: 10.7554/eLife.00291
PMCID: PMC3576711

Genes

TLR7
TLR9
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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