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Article

Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization.

The Journal of biological chemistry - 21 Sept 2012

Qi Rongsu, Singh Divyendu, Kao C Cheng

Abstract excerpt

Toll-like receptors (TLRs) 3, 7, and 9 are innate immune receptors that recognize nucleic acids from pathogens in endosomes and initiate signaling transductions that lead to cytokine production. Activation of TLR9 for signaling requires proteolytic processing within the ectodomain by endosome-associated proteases. Whether TLR3 requires similar proteolytic processing to become competent for signaling remains...

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Topics

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Share to Endosomes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

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Share to Protein Stability

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Share to Toll-Like Receptor 3

Source

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Identifiers

PMID: 22865861
DOI: 10.1074/jbc.M112.387803
PMCID: PMC3463343

Genes

TLR3
TLR9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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