Article

Endosome dysfunction leads to gain-of-function TLR7 and human lupus

2023-04-03

Abstract excerpt

Hyperactive Toll-like receptor (TLR) 7 signaling has long been appreciated as a driver of autoimmune disease by breaking tolerance to self-nucleic acids in mouse models 1–5 . Recently, mutations in TLR7 or its associated regulator UNC93B1 6, 7 , were identified as monogenic causes of human lupus; the unifying feature of these mutations being TLR7 gain-of-function. TLR7 is an intracellular transmembrane receptor,...

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Literature Corpus work: 9a1eaa8b-9779-56d2-afcc-088a60e64166
DOI: 10.1101/2023.04.03.535356

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