Article

Non-canonical aberrant DNA hypermethylation in glioma

2017-09-26

Abstract excerpt

Aberrant DNA hypermethylation is a hallmark of cancer although the underlying molecular mechanisms are still poorly understood. To study the possible role of 5-hydroxymethylcytosine (5hmC) in this process we analyzed the global and locus-specific genome-wide levels of 5hmC in primary samples from 54 gliomas and 72 colorectal cancer patients. Levels of 5hmC in colorectal cancer were very low and no consistent chang...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6e9dd502-63b4-55a4-bcbc-c7af28b5c9e8
DOI: 10.1101/193789

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Non-canonical aberrant DNA hypermethylation in gliomaDOI 10.1101/193789Read

Region-specific DNA hydroxymethylation along the malignant progression of IDH-mutant gliomas.Semantic proximity Read

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma.Semantic proximity Read

Glioma CpG Island Methylator Phenotype (G-CIMP): Biological and Clinical ImplicationsSemantic proximity Read

Epigenetic dysregulation in glioma.Semantic proximity Read

Methylation and transcription patterns are distinct in IDH mutant gliomas compared to other IDH mutant cancersSemantic proximity Read

DNA hypohydroxymethylation in pediatric central nervous system tumors is associated with CTCF binding sites and reduced survivalSemantic proximity Read

Germline-driven replication repair-deficient high-grade gliomas exhibit unique hypomethylation patternsSemantic proximity Read

Comparing the DNA hypermethylome with gene mutations in human colorectal cancer.Semantic proximity Read

Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal CancerSemantic proximity Read

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced de-novo mutation in survival outliers of glioblastomaSemantic proximity Read

Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas.Semantic proximity Read

MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human gliomaSemantic proximity Read