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Article

MiR-185 Targets the DNA Methyltransferases 1 and Regulates Global DNA Methylation in human glioma

30 Sept 2011

Abstract excerpt

BACKGROUND: Perturbation of DNA methylation is frequent in cancers and has emerged as an important mechanism involved in tumorigenesis. To determine how DNA methylation is modified in the genome of primary glioma, we used Methyl-DNA immunoprecipitation (MeDIP) and Nimblegen CpG promoter microarrays to identify differentially DNA methylation sequences between primary glioma and normal brain tissue samples....

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PMID: 21962230
DOI: 10.1186/1476-4598-10-124

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