Back to search

Article

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

2023-11-05

Abstract excerpt

Human papillomavirus (HPV) integration has been implicated in transforming HPV infection into cancer, but its genomic consequences have been difficult to study using short-read technologies. To resolve the dysregulation associated with HPV integration, we performed long-read sequencing on 63 cervical cancer genomes. We identified six categories of integration events based on HPV-human genomic structures. Of all HP...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6e9a7eae-c4e4-5bc0-9d78-778e2da20439
DOI
10.1101/2023.11.04.564800
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genomic structures and regulation patterns at HPV integration sites in cervical cancerDOI 10.1101/2023.11.04.564800
Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation.Semantic proximity
Genomic characterization of viral integration sites in HPV‐related cancersSemantic proximity
Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancerSemantic proximity
Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesisSemantic proximity
Cis‐regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancersSemantic proximity
Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?Semantic proximity
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanismSemantic proximity
Identification of human papillomavirus (HPV) 16 DNA integration and the ensuing patterns of methylation in HPV-associated head and neck squamous cell carcinoma cell lines.Semantic proximity
Transcriptionally Active Regions Are the Preferred Targets for Chromosomal HPV Integration in Cervical CarcinogenesisSemantic proximity
Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell linesSemantic proximity
Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancersSemantic proximity
Analysis of HPV Integrations in Mexican Pre-Tumoral Cervical Lesions Reveal Centromere-Enriched Breakpoints and Abundant Unspecific HPV Regions.Semantic proximity
Select a neighboring publication to make it the new centre.