Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analysis of HPV Integrations in Mexican Pre-Tumoral Cervical Lesions Reveal Centromere-Enriched Breakpoints and Abundant Unspecific HPV Regions.

International journal of molecular sciences - 22 Mar 2021

Garza-Rodríguez María Lourdes, Oyervides-Muñoz Mariel Araceli, Pérez-Maya Antonio Alí, Sánchez-Domínguez Celia Nohemí, Berlanga-Garza Anais, Antonio-Macedo Mauro, Valdés-Chapa Lezmes Dionicio, Vidal-Torres Diego, Vidal-Gutiérrez Oscar, Pérez-Ibave Diana Cristina, Treviño Víctor

Abstract excerpt

Human papillomavirus (HPV) DNA integration is a crucial event in cervical carcinogenesis. However, scarce studies have focused on studying HPV integration (HPVint) in early-stage cervical lesions. Using HPV capture followed by sequencing, we investigated HPVint in pre-tumor cervical lesions. Employing a novel pipeline, we analyzed reads containing direct evidence of the integration breakpoint. We observed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Viral
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mexico

Share to Papillomaviridae

Share to Papillomavirus Infections

Share to Precancerous Conditions

Share to Uterine Cervical Dysplasia

Share to Virus Integration

Source

Open in PubMed Open full text

Identifiers

PMID: 33810183
DOI: 10.3390/ijms22063242
PMCID: PMC8005155

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of HPV Integrations in Mexican Pre-Tumoral Cervical Lesions Reveal Centromere-Enriched Breakpoints and Abundant Unspecific HPV Regions.PMID 33810183Read ↗

Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancerSemantic proximity Read ↗

Genomic characterization of viral integration sites in HPV‐related cancersSemantic proximity Read ↗

Genomic structures and regulation patterns at HPV integration sites in cervical cancerSemantic proximity Read ↗

Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubsSemantic proximity Read ↗

Rearrangements of viral and human genomes at human papillomavirus integration events and their allele-specific impacts on cancer genome regulation.Semantic proximity Read ↗

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanismSemantic proximity Read ↗

Multiple HPV integration mode in the cell lines based on long-reads sequencingSemantic proximity Read ↗

Mechanistic signatures of HPV insertions in cervical carcinomasSemantic proximity Read ↗

Human papillomavirus genome integration in squamous carcinogenesis: what have next‐generation sequencing studies taught us?Semantic proximity Read ↗

Recurrent Integration of Human Papillomavirus Genomes at Transcriptional Regulatory HubsSemantic proximity Read ↗

Genome‐wide virus‐integration analysis reveals a common insertional mechanism of HPV, HBV and EBVSemantic proximity Read ↗

Transcriptionally Active Regions Are the Preferred Targets for Chromosomal HPV Integration in Cervical CarcinogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.