Article
Identification of human papillomavirus (HPV) 16 DNA integration and the ensuing patterns of methylation in HPV-associated head and neck squamous cell carcinoma cell lines.
International journal of cancer - 1 Apr 2017
Hatano Takashi, Sano Daisuke, Takahashi Hideaki, Hyakusoku Hiroshi, Isono Yasuhiro, Shimada Shoko, Sawakuma Kae, Takada Kentaro, Oikawa Ritsuko, Watanabe Yoshiyuki, Yamamoto Hiroyuki, Itoh Fumio, Myers Jeffrey N, Oridate Nobuhiko
Abstract excerpt
Recent studies showed that human papillomavirus (HPV) integration contributes to the genomic instability seen in HPV-associated head and neck squamous cell carcinoma (HPV-HNSCC). However, the epigenetic alterations induced after HPV integration remains unclear. To identify the molecular details of HPV16 DNA integration and the ensuing patterns of methylation in HNSCC, we performed next-generation sequencing using...
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