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Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis

1 May 2023

Abstract excerpt

Integration of human papilloma virus (HPV) DNA into the human genome may progressively contribute to cervical carcinogenesis. To explore how HPV integration affects gene expression by altering DNA methylation during carcinogenesis, we analyzed a multiomics dataset for cervical cancer. We obtained multiomics data by HPV-capture sequencing, RNA sequencing, and Whole Genome Bisulfite Sequencing from 50 patients with...

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Cancer-related molecular mechanisms research
Cervical Cancer and HPV Research
Epigenetics and DNA Methylation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37212325
DOI: 10.1002/jmv.28789

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