Article

Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

2022-11-28

Abstract excerpt

Human papillomavirus (HPV) infections are the primary drivers of cervical cancers, and often the HPV DNA gets integrated into the host genome. Although the oncogenic impact of HPV encoded genes (such as E6/E7) is well known, the cis-regulatory effect of integrated HPV DNA on host chromatin structure and gene regulation remains less understood. Here, we investigate the genome-wide patterns of HPV integrations and a...

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Literature Corpus work: 9cca903f-62b7-5c5e-aefd-7bf3e31339f9
DOI: 10.1101/2022.11.28.518229

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