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Article

Cis‐regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

28 Nov 2023

Abstract excerpt

Human papillomavirus (HPV) infections are the primary drivers of cervical cancers, and often HPV DNA gets integrated into the host genome. Although the oncogenic impact of HPV encoded genes is relatively well known, the cis-regulatory effect of integrated HPV DNA on host chromatin structure and gene regulation remains less understood. We investigated genome-wide patterns of HPV integrations and associated host...

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PMID: 38013620
DOI: 10.1002/1878-0261.13559

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