Article

Accelerated Adaptation of SARS-CoV-2 Variants in Mice Lacking IFITM3 Preserves Distinct Tropism and Pathogenesis

2025-01-28

Abstract excerpt

<h4>ABSTRACT</h4> Here we investigated whether interferon induced transmembrane protein 3 (IFITM3), a key antiviral protein deficient in certain human populations, affects interspecies adaptation of SARS-CoV-2. We found that SARS-CoV-2 Beta and Omicron variants passaged through IFITM3-deficient versus wild type mice exhibit enhanced replication and pathogenesis in this new host species. Enhancements associated wi...

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Literature Corpus work: 6e93cc83-5dce-50ab-92e5-8b96e20bfc48
DOI: 10.1101/2025.01.27.635150

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