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SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice

13 Jan 2023

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved to variants associated with milder disease. We employed the k18-hACE2 mouse model to study how differences in the course of infection by SARS-CoV-2 variants alpha, delta, and omicron relate to tissue pathology and the immune response triggered. We documented a variant-specific pattern of infection severity, inducing discrete lung and blood...

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PMID: 36687317
DOI: 10.1016/j.isci.2023.105972

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