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Article

IFITM3 deficiency drives SARS-CoV-2 adaptation while preserving variant-specific traits.

Nature communications - 29 Jan 2026

Denz Parker J, Speaks Samuel, McFadden Matthew I, Cable Jana M, Aladhami Ahmed K, Papa Jonathan L, Rayner Rachael E, Rao Prerana R, Leumi Steve, Roettger Jack E, Dhariwala Miqdad O, Cormet-Boyaka Estelle, Forero Adriana, Yount Jacob S

Abstract excerpt

SARS-CoV-2 can infect and adapt to multiple animal species, yet the host determinants that control interspecies viral adaptation remain poorly defined. Here we investigate whether interferon-induced transmembrane protein 3 (IFITM3), a key antiviral protein deficient in certain human populations, affects interspecies adaptation of SARS-CoV-2. We find that SARS-CoV-2 Beta and Omicron BA.4 variants passaged through...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41611675
DOI: 10.1038/s41467-026-68485-2
PMCID: PMC12917256

Genes

IFITM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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