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Gαs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling.

Pharmacological reviews - 1 Oct 2021

Ramms Dana J, Raimondi Francesco, Arang Nadia, Herberg Friedrich W, Taylor Susan S, Gutkind J Silvio

Abstract excerpt

Many of the fundamental concepts of signal transduction and kinase activity are attributed to the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A. PKA is one of the best-studied kinases in human biology, with emphasis in biochemistry and biophysics, all the way to metabolism, hormone action, and gene expression regulation. It is surprising, however, that our understanding of...

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Identifiers

PMID: 34663687
DOI: 10.1124/pharmrev.120.000269
PMCID: PMC11060502

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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