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Article

Local protein kinase A signaling pathologies in the endocrine system.

Molecular pharmacology - 1 Jan 2026

Cleveland Kristan H, Scott John D

Abstract excerpt

Endocrine signaling relies heavily on the second messenger cAMP to influence different functional outcomes including hormone secretion, steroidogenesis, ion channel regulation, and cell growth. Selectivity of cAMP action is often achieved through compartmentalized activation of protein kinase A (PKA). Local PKA action is organized by A-kinase anchoring proteins. These organellar enzyme scaffolds not only define...

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PMID: 42241862
DOI: 10.1016/j.molpha.2026.100128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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