Article
Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Proceedings of the National Academy of Sciences of the United States of America - 25 May 2021
Jafari Naeimeh, Del Rio Jason, Akimoto Madoka, Byun Jung Ah, Boulton Stephen, Moleschi Kody, Alsayyed Yousif, Swanson Pascale, Huang Jinfeng, Martinez Pomier Karla, Lee Chi, Wu Jian, Taylor Susan S, Melacini Giuseppe
Abstract excerpt
Familial mutations of the protein kinase A (PKA) R1α regulatory subunit lead to a generalized predisposition for a wide range of tumors, from pituitary adenomas to pancreatic and liver cancers, commonly referred to as Carney complex (CNC). CNC mutations are known to cause overactivation of PKA, but the molecular mechanisms underlying such kinase overactivity are not fully understood in the context of the...
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