Article
PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease.
Structure (London, England : 1993) - 7 Jan 2014
Bruystens Jessica G H, Wu Jian, Fortezzo Audrey, Kornev Alexandr P, Blumenthal Donald K, Taylor Susan S
Abstract excerpt
The regulatory (R) subunit is the cAMP receptor of protein kinase A. Following cAMP binding, the inactive PKA holoenzyme complex separates into two active catalytic (C) subunits and a cAMP-bound R dimer. Thus far, only monomeric R structures have been solved, which fell short in explaining differences of cAMP binding for the full-length protein as compared to the truncated R subunits. Here we solved a full-length...
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