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Article

Amyloid-Driven Allostery.

Biophysical chemistry - 1 Dec 2024

Garcha Jaskiran, Huang Jinfeng, Martinez Pomier Karla, Melacini Giuseppe

Abstract excerpt

The fields of allostery and amyloid-related pathologies, such as Parkinson's disease (PD), have been extensively explored individually, but less is known about how amyloids control allostery. Recent advancements have revealed that amyloids can drive allosteric effects in both intrinsically disordered proteins, such as alpha-synuclein (αS), and multi-domain signaling proteins, such as protein kinase A (PKA)....

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PMID: 39278064
DOI: 10.1016/j.bpc.2024.107320

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