Article

Impact of suboptimal APOBEC3G neutralization on the emergence of HIV drug resistance in humanized mice

2019-09-11

Abstract excerpt

<h4>ABSTRACT</h4> HIV diversification facilitates immune escape and complicates antiretroviral therapy. In this study, we take advantage of a humanized mouse model to probe the contribution of APOBEC3 mutagenesis to viral evolution. Humanized mice were infected with isogenic HIV molecular clones (HIV-WT, HIV-45G, HIV-ΔSLQ) that differ only in their ability to counteract APOBEC3G (A3G). Infected mice remained naïv...

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Literature Corpus work: 6e17d5bc-e51e-5980-8bb2-4fd3e4245e8c
DOI: 10.1101/764381

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