Article

HIV broadly neutralizing antibody escape dynamics drive the outcome of AAV vectored immunotherapy in humanized mice

2024-07-12

Abstract excerpt

<h4>Summary</h4> Broadly neutralizing antibodies (bNAbs) have shown promise for prevention and treatment of HIV. Potency and breadth measured in vitro are often used as predictors of clinical potential; however, human studies demonstrate that clinical efficacy of bNAbs can be undermined by both pre-existing and de novo resistance. Here we find that HIV-infected humanized mice receiving bNAbs delivered via AAV a...

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Literature Corpus work: 8f529cea-adae-5cac-8e8b-40de4cadf476
DOI: 10.1101/2024.07.11.603156

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