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Article

Impact of Suboptimal APOBEC3G Neutralization on the Emergence of HIV Drug Resistance in Humanized Mice.

Journal of virology - 14 Feb 2020

Hernandez Matthew M, Fahrny Audrey, Jayaprakash Anitha, Gers-Huber Gustavo, Dillon-White Marsha, Audigé Annette, Mulder Lubbertus C F, Sachidanandam Ravi, Speck Roberto F, Simon Viviana

Abstract excerpt

HIV diversification facilitates immune escape and complicates antiretroviral therapy. In this study, we take advantage of a humanized-mouse model to probe the contribution of APOBEC3 mutagenesis to viral evolution. Humanized mice were infected with isogenic HIV molecular clones (HIV-WT, HIV-45G, and HIV-ΔSLQ) that differ in their abilities to counteract APOBEC3G (A3G). Infected mice remained naive or were treated...

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Identifiers

PMID: 31801862
DOI: 10.1128/JVI.01543-19
PMCID: PMC7022346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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