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Article

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy.

Antiviral research - 1 Mar 2017

Khera Tanvi, Todt Daniel, Vercauteren Koen, McClure C Patrick, Verhoye Lieven, Farhoudi Ali, Bhuju Sabin, Geffers Robert, Baumert Thomas F, Steinmann Eike, Meuleman Philip, Pietschmann Thomas, Brown Richard J P

Abstract excerpt

Due to the highly restricted species-tropism of Hepatitis C virus (HCV) a limited number of animal models exist for pre-clinical evaluation of vaccines and antiviral compounds. The human-liver chimeric mouse model allows heterologous challenge with clinically relevant strains derived from patients. However, to date, the transmission and longitudinal evolution of founder viral populations in this model have not...

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Identifiers

PMID: 28062191
DOI: 10.1016/j.antiviral.2017.01.001
PMCID: PMC5292934

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