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Article

APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model.

PLoS pathogens - 1 Oct 2014

Sato Kei, Takeuchi Junko S, Misawa Naoko, Izumi Taisuke, Kobayashi Tomoko, Kimura Yuichi, Iwami Shingo, Takaori-Kondo Akifumi, Hu Wei-Shau, Aihara Kazuyuki, Ito Mamoru, An Dong Sung, Pathak Vinay K, Koyanagi Yoshio

Abstract excerpt

Several APOBEC3 proteins, particularly APOBEC3D, APOBEC3F, and APOBEC3G, induce G-to-A hypermutations in HIV-1 genome, and abrogate viral replication in experimental systems, but their relative contributions to controlling viral replication and viral genetic variation in vivo have not been elucidated. On the other hand, an HIV-1-encoded protein, Vif, can degrade these APOBEC3 proteins via a ubiquitin/proteasome...

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Identifiers

PMID: 25330146
DOI: 10.1371/journal.ppat.1004453
PMCID: PMC4199767

Genes

CCR5
CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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