Article
HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation.
PLoS pathogens - 1 May 2017
Nakano Yusuke, Misawa Naoko, Juarez-Fernandez Guillermo, Moriwaki Miyu, Nakaoka Shinji, Funo Takaaki, Yamada Eri, Soper Andrew, Yoshikawa Rokusuke, Ebrahimi Diako, Tachiki Yuuya, Iwami Shingo, Harris Reuben S, Koyanagi Yoshio, Sato Kei
Abstract excerpt
APOBEC3 (A3) family proteins are DNA cytosine deaminases recognized for contributing to HIV-1 restriction and mutation. Prior studies have demonstrated that A3D, A3F, and A3G enzymes elicit a robust anti-HIV-1 effect in cell cultures and in humanized mouse models. Human A3H is polymorphic and can be categorized into three phenotypes: stable, intermediate, and unstable. However, the anti-viral effect of endogenous...
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