Article
The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model.
Retrovirology - 30 Jun 2016
Cadena Cristhian, Stavrou Spyridon, Manzoni Tomaz, Iyer Shilpa S, Bibollet-Ruche Frederic, Zhang Weiyu, Hahn Beatrice H, Browne Edward P, Ross Susan R
Abstract excerpt
Humans encode seven APOBEC3 proteins (A-H), with A3G, 3F and 3H as the major factors restricting HIV-1 replication. HIV-1, however, encodes Vif, which counteracts A3 proteins by chaperoning them to the proteasome where they are degraded. Vif polymorphisms found in HIV-1s isolated from infected patients have varying anti-A3G potency when assayed in vitro, but there are few studies demonstrating this in in vivo...
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