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Article

Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission.

Journal of medical primatology - 1 Oct 2020

Schmitt Kimberly, Curlin James, Remling-Mulder Leila, Moriarty Ryan, Goff Kelly, O'Connor Shelby, Stenglein Mark, Marx Preston, Akkina Ramesh

Abstract excerpt

HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4+ T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33460210
DOI: 10.1111/jmp.12485
PMCID: PMC8177655

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