Article
Evolution of SIVsm in humanized mice towards HIV-2.
Journal of medical primatology - 1 Oct 2020
Curlin James, Schmitt Kimberly, Remling-Mulder Leila, Moriarty Ryan, Goff Kelly, O'Connor Shelby, Stenglein Mark, Marx Preston, Akkina Ramesh
Abstract excerpt
Through the accumulation of adaptive mutations, HIV-2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross-species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T-cell decline as the virus was passaged in humanized mice.
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