Activation of RAS/MEK/ERK signalling drives biliary differentiation in primary liver cancer.

doi:10.1136/gutjnl-2024-333238

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Article

Activation of RAS/MEK/ERK signalling drives biliary differentiation in primary liver cancer.

Gut - 8 Sept 2025

Rösner Thomas, Rupp Carina, Lechler Christian, Bauer Ulrike, Manmadhan Saumya Sukumary, Bernatik Sophia, Delugré Fabian, Ihli Franziska, Derowski Tanja, Jörs Simone, Kohnke-Ertel Birgit, Einwächter Henrik, Pfarr Nicole, Steiger Katja, Mogler Carolin, Reichert Maximilian, Saur Dieter, Becker Diana, Marquardt Jens U, Öllinger Rupert, Engleitner Thomas, Rad Roland, Schmid Roland M, Ehmer Ursula

Abstract excerpt

BACKGROUND: RAS mutations are frequently observed in human cholangiocarcinoma (CCA), while they are relatively rare in hepatocellular carcinoma (HCC). The role of RAS-dependent signalling pathways in CCA development is currently not well understood. OBJECTIVE: The objective of this study was to investigate RAS-dependent signalling pathways in CCA and their role in tumour development and differentiation. DESIGN:...

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Identifiers

PMID: 40355258
DOI: 10.1136/gutjnl-2024-333238

Genes

KRAS

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