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Article

Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2013

Saborowski Anna, Saborowski Michael, Davare Monika A, Druker Brian J, Klimstra David S, Lowe Scott W

Abstract excerpt

Cholangiocarcinoma is the second most common primary liver cancer and responds poorly to existing therapies. Intrahepatic cholangiocarcinoma (ICC) likely originates from the biliary tree and develops within the hepatic parenchyma. We have generated a flexible orthotopic allograft mouse model of I...

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Share to Bile Duct Neoplasms
Share to Bile Ducts, Intrahepatic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24154728
DOI: 10.1073/pnas.1311707110
PMCID: PMC3845141

Genes

ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24154728-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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