Article
Loss of BAP1 Expression Occurs Frequently in Intrahepatic Cholangiocarcinoma.
Medicine - 1 Jan 2016
Andrici Juliana, Goeppert Benjamin, Sioson Loretta, Clarkson Adele, Renner Marcus, Stenzinger Albrecht, Tayao Michael, Watson Nicole, Farzin Mahtab, Toon Christopher W, Smith Ross C, Mittal Anubhav, Samra Jaswinder S, Hugh Thomas J, Chou Angela, Lawlor Rita T, Weichert Wilko, Schirmacher Peter, Sperandio Nicola, Ruzzenente Andrea, Scarpa Aldo, Gill Anthony J
Abstract excerpt
BRCA1-associated protein 1 (BAP1) is a deubiquitinating enzyme that functions as a tumor suppressor gene. Double hit BAP1 inactivation has been reported in a range of tumor types, including intrahepatic cholangiocarcinoma (ICC), sometimes in association with germline mutation.We performed immunohistochemistry for BAP1 on a well-characterized cohort of 211 ICC patients undergoing surgical resection with curative...
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