Article
Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.
Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2020
Hayakawa Hideki, Nakatani Rie, Ikenaka Kensuke, Aguirre Cesar, Choong Chi-Jing, Tsuda Hiroshi, Nagano Seiichi, Koike Masato, Ikeuchi Takeshi, Hasegawa Masato, Papa Stella M, Nagai Yoshitaka, Mochizuki Hideki, Baba Kousuke
Abstract excerpt
OBJECTIVE: Alpha-synuclein (α-syn) is a major component of Lewy bodies, which are the pathological hallmark in Parkinson's disease, and its genetic mutations cause familial forms of Parkinson's disease. Patients with α-syn G51D mutation exhibit severe clinical symptoms. However, in vitro studies showed low propensity for α-syn with the G51D mutation. We studied the mechanisms associated with severe neurotoxicity...
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