Article

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

2021-10-05

Abstract excerpt

Cancer cells often co-opt post-transcriptional regulatory mechanisms to achieve pathologic expression of gene networks that drive metastasis. Translational control is a major regulatory hub in oncogenesis, however its effects on cancer progression remain poorly understood. To address this, we used ribosome profiling to compare genome-wide translation efficiencies of poorly and highly metastatic breast cancer cells...

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Literature Corpus work: 6dcac13d-14c6-5ec3-a230-e9ee5cf4b7c1
DOI: 10.1101/2021.10.04.463118

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