Article

Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma

2022-06-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Radiation therapy (RT) is essential for the management of glioblastoma (GBM). However, GBM frequently relapses within the irradiated margins, thus suggesting that RT might stimulate mechanisms of resistance that limits its efficacy. GBM is recognized for its metabolic plasticity, but whether RT-induced resistance relies on metabolic adaptation remains unclear. <h4>Methods</h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b7e1c27-c84b-5a83-826d-cb6b02e64f45
DOI: 10.1101/2022.06.01.494338

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastomaDOI 10.1101/2022.06.01.494338Read

Glioblastomas: Hijacking Metabolism to Build a Flexible Shield for Therapy ResistanceSemantic proximity Read

FASN Inhibition Resensitizes Chordoma to Radiotherapy by Targeting Adaptive Unsaturated Fatty Acid MetabolismSemantic proximity Read

Temozolomide Treatment Increases Fatty Acid Uptake in Glioblastoma Stem CellsSemantic proximity Read

Enhanced fatty acid oxidation provides glioblastoma cells metabolic plasticity to accommodate to its dynamic nutrient microenvironment.Semantic proximity Read

Methodological Approaches for Assessing Metabolomic Changes in Glioblastomas.Semantic proximity Read

Divergent MEK/ERK and AMPK signaling dictate lipogenic plasticity and dependence on fatty acid synthesis in GlioblastomaSemantic proximity Read

Enhanced lipid metabolism serves as a metabolic vulnerability to a polyunsaturated fatty acid (PUFA)-rich diet in glioblastomaSemantic proximity Read

Altered lipid metabolism marks glioblastoma stem and non-stem cells in separate tumor nichesSemantic proximity Read

Autophagy–Cholesterol Axis Remodeling Supports Malignant Progression and Chemoresistance in GliomaSemantic proximity Read

Advancing glioblastoma treatment by targeting metabolismSemantic proximity Read

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistanceSemantic proximity Read

Medium-chain acyl-CoA dehydrogenase, a gatekeeper of mitochondrial function in glioblastoma multiformeSemantic proximity Read