Article

NOTCH3 Drives Fatty Acid Oxidation and Ferroptosis Resistance in Aggressive Meningiomas

2025-06-04

Abstract excerpt

<title>Abstract</title> <p>PURPOSE <italic>NOTCH3</italic> is increasingly implicated for its oncogenic role in many malignancies, including meningiomas. While prior work has linked <italic>NOTCH3</italic> expression to higher-grade meningiomas and treatment resistance, the metabolic phenotype of <italic>NOTCH3</italic> activation remains unexplored in meningioma. METHODS We performed single-cell RNA sequencing...

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Literature Corpus work: 164ca494-b58e-5222-b0db-9bdc5ac12c54
DOI: 10.21203/rs.3.rs-6779386/v1

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