Article

The Lipid Switch: Ultra-High Dose Omega Fatty Acids Determine MYCN Neuroblastoma Fate Through Oxylipin Competition

2025-10-17

Abstract excerpt

High-risk neuroblastoma (NB) remains a lethal pediatric cancer, and low-toxicity strategies are urgently needed. Using a syngeneic MYCN-driven model, we tested ultra-high dose oral arachidonic acid (ARA, ω6, 4.7 g/d hEq) and docosahexaenoic acid (DHA, ω3, 24 g/d hEq) as modifiers of tumorigenesis. ARA strikingly accelerated tumor growth, producing 100% tumor incidence and solid tumors without necrosis, and fourfol...

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Literature Corpus work: 63288a11-1994-579e-ba46-4804df77bf74
DOI: 10.20944/preprints202510.1399.v1

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