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Article

Harnessing m6A-regulated cholesterol biosynthesis helps impede tumor burden and stemness in high-garde serous ovarian carcinoma mesenchymal phenotype.

Molecular medicine (Cambridge, Mass.) - 29 Dec 2025

Narayanan Aravindan, Dhenge Kiran, Bapat Sharmila A

Abstract excerpt

Post-transcriptional RNA modifications have emerged as critical regulators of stemness, cellular plasticity, adaptation to stress and transformation. Amongst these the N6-methyladenosine (m6A) modification orchestrates a wide range of physiological processes; yet its contribution to metabolic regulation remains poorly addressed. In the present study, differential proteomics revealed enrichment of core components...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystadenocarcinoma, Serous

Share to Gene Expression Regulation, Neoplastic

Share to Neoplastic Stem Cells

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Source

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Identifiers

PMID: 41466215
DOI: 10.1186/s10020-025-01413-0
PMCID: PMC12859830

Genes

IGF2BP3
WTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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