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Integrated analysis of single cell and spatial transcriptomics revealed a metastasis mechanism mediated by fatty acid metabolism in lymph nodes of head and neck cancer

13 Aug 2025

Abstract excerpt

Introduction: Head and neck squamous cell carcinoma (HNSCC) was a common malignant tumor, and its recurrence and metastasis during treatment were the main factors affecting the patient's prognosis. This study aimed to explore the evolutionary mechanisms during HNSCC metastasis. Methods: This study collected single-cell RNA sequencing (scRNA-seq), spatial transcriptome (ST) data, and fatty acid metabolism-related...

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PMID: 40881692
DOI: 10.3389/fimmu.2025.1614498

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