SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function

Abstract excerpt

NAD⁺ supplementation blunts Th1 and Th17 inflammation, in part, through arginine metabolism-dependent regulation of mitochondrial energetics, redox balance and signal transduction. Whether the NAD + -dependent sirtuin deacylases contribute to this regulation is unknown. Here, we show that both SIRT1 and SIRT5 transcript levels are induced in CD4 + T cells in human participants following oral supplementation of t...

Topics

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• Autophagy in Disease and Therapy
• Cell Differentiation
• Cytomegalovirus and herpesvirus research
• Energy Metabolism
• Immune System
• Immunity
• Mitochondria
• Sirtuins and Resveratrol in Medicine

Identifiers and source

Literature Corpus work

6db3cb50-d280-538b-9c0a-acda9705051d

DOI

10.64898/2026.06.24.734337